XANAX

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Drug overview: Alprazolam is a benzodiazepine with an intermediate onset of action. It is best know by the brand name Xanax (pronounce zan~ax). It was introduce as a treatment for anxiety and panic disorders in the US in 1981 and became a popular recreational drug.

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Background: Although reports of alprazolam use and adulteration date back a decade or more2 the recreational use of benzodiazepines in the UK has typically involved those prescribed by the NHS, in particular diazepam divert from regulate supplies or import.

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A number of unlicense benzodiazepines, such as phenazepam and etizolam have emerge on the new psychoactive substance (NPS) market in the last decade. The availability and popularity of alprazolam in the UK appears relatively recent. The current size of the illicit UK benzodiazepine market is unknow, but a 2018 parliamentary debate report that over 130 million benzodiazepines and other hypnotics were diverted from the regulate supply chain in the last three years. Alprazolam account for over 3% of total UK dark-web trades in a 2017 study.

There are no accurate UK estimates of alprazolam prevalence but there are numerous indications that the drug has become more widely available and popular for both self medication and as a recreational drug.

Availability: Alprazolam is not available on the NHS,
but is available in 0.25mg (250mcg) and 0.5mg (500mcg) tablets with a private/online prescription.
Other websites offer alprazolam in 1mg and 2mg doses without a prescription

User forums and local intelligence suggest alprazolam is readily available in
1mg tablets and 2mg bars from street deals and from foreign and crypto (dark-web) markets.
It is believe that counterfeit Xanax can be more potent than the state dose and/
or may also be selling in more potent ‘pressed high dose’ form.

Chemical name: 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a] [1,4]benzodiazepine. Brain chemistry: Alprazolam, like other benzodiazepines, binds to benzodiazepine receptors (BZR) which in turn change how GABA-A receptors function. Benzodiazepines effectively “enhance” the effect of GABA at GABA receptors, reducing electrical charge within neurons.

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